Johnny Rizzo, is about to trade his dream job in talk radio for some snooze-ville gig that'll pay enough to please his fiancée. Enter Uncle Terry, a rascally womanizer set on turning a weekend in the Hamptons into an eye-opening fling for his nephew. Nice guy Johnny's not interested, of course, but then he meets the lovely Brooke, who challenges Johnny to make the toughest decision of is life.

Jean is a woman who is hiding from life after an accident leaves her wheelchair-bound. Joey is her friend who speaks to ghosts and angels no one else can see or hear. When he reads in the newspaper that his favorite author will be speaking in New Orleans, he convinces Jean to go with him. Along the way, they meet up with Billie, a young woman in search of her missing husband. The travelers have many obstacles in their path. They meet many different "angels" and "devils" along the way. Will they make it in time for the most important gig of Jean's life?

Santos attempts to lead a people's revolt in Colombia to overthrow the oppressive El Presidente. When his revolt fails and he is killed, his sister Christina goes to New York to find McBain, a lieutenant Santos rescued during the Vietnam War. McBain agrees to avenge Santos' death, calls up his old war buddies, raises the necessary funds by killing a few drug dealers and threatening the mafia, then leads an attack to topple the corrupt government.

Seth is an angel who accompanies the spirits of the recently dead to the ever after. Seth has never been human and so has has never experienced touch or taste. When in the hospital however he comes across Dr. Maggie Rice, a brilliant young heart surgeon who is devoted to her profession and her patients. Seth has the power to let himself be seen but Maggie finds him far too mysterious. Seth also meets a patient, Nathaniel Messinger, who has news for him - he too was once an angel like Seth but chose to fall to Earth and become human. Seth makes a decision on his future, which does not turn out as he had expected.